The course was organised by RA-COURSES in collaboration with CASCADE Network of Excellence and the Postgraduate programme in Environmental Factors and Health at Karolinska Institutet.
Course participants and teachers at the course in Receptor-mediated toxicity.
The objective of the course was to provide state-of-the-art knowledge of toxicological mechanisms mediated by hormone receptors and endocrine signalling pathways.
The course included the following topics: Molecular mechanisms of hormone receptor signalling, Signalling pathways targeted by endocrine disrupting chemicals, Emerging techniques to identify and screen for endocrine disrupters and Risk assessment of endocrine disruptors.
The course consisted of lectures, group work, methods workshop and project work.
The intended learning outcome was understanding of molecular mechanisms of endocrine disruption and its implications for risk assessment as well as new methodological tools for own research in the topic.
Teachers: Patrick Balaguer, INSERM, Montpellier, France Maria Bondesson, Karolinska Institutet, Stockholm, Sweden Antonio Chana, Mario Negri Institute, Milano, Italy Tomas Ekström, Karolinska Institutet, Stockholm, Sweden Lars-Arne Haldosén, Karolinska Institutet, Stockholm, Sweden Annika Hanberg, Karolinska Institutet, Stockholm, Sweden Matti Poutanen, University of Turku, Turku, Finland Agneta Rannug, Karolinska Institutet, Stockholm, Sweden Johanna Zilliacus, Karolinska Institutet, Stockholm, Sweden
Course organiser: Johanna Zilliacus, Karolinska Institutet, Sweden.
Course committee: Johanna Zilliacus, Agneta Rannug and Helen Håkansson, Karolinska Institutet, Sweden and Patrik Andersson, Umeå University, Sweden.
2. Health risk assessment I: Principles and applications
April 14-18, 2008
Karolinska Institutet, Stockholm, Sweden
The course was organised by RA-COURSES in collaboration with CASCADE Network of Excellence and the Postgraduate programme in Environmental Factors and Health at Karolinska Institutet.
Course participants and teachers at the course in Health risk assessment I: Principles and Applications.
The objective of the course was to provide knowledge and understanding of the methods and principles used in health risk assessment and to familiarize participants with the general procedures used in health risk assessments.
The course included the following topics: fundamental concepts in toxicology and risk assessment, epidemiology, exposure assessment; risk assessment in regulatory decision-making, critical effects, extrapolation, uncertainty factors and allocation of health-based guidance values; interpretation possibilities and evaluation of data from different test systems, handling of uncertainties and data gaps, and other problems in health risk assessment.
The course consisted of lectures and group work.
The intended learning outcome was that the student shall have acquired knowledge and understanding of the methods and procedures used in health risk assessment. The student shall also have aquired a professional attitude in interpretation of toxicological and epidemiological studies for use in health risk assessment.
Teachers: Marika Berglund, Karolinska Institutet, Stockholm, Sweden Anna Bergström, Karolinska Institutet, Stockholm, Sweden Daniel Borg, Karolinska Institutet, Stockholm, Sweden Bert Ove Lund, Swedish Chemicals Agency, Sweden Annika Hanberg, Karolinska Institutet, Stockholm, Sweden Claudia Heppner, European Food Safety Authority Helen Håkansson, Karolinska Institutet, Stockholm, Sweden Gunnar Johanson, Karolinska Institutet, Stockholm, Sweden Torbjörn Malmfors, Malmfors Consulting, Sweden Göran Pershagen, Karolinska Institutet, Stockholm, Sweden Agneta Rannug, Karolinska Institutet, Stockholm, Sweden Christina Rudén, Royal Institute of Technology, Stockholm, Sweden Katarina Victorin, Karolinska Institutet, Stockholm, Sweden Lars Wiklund, RegSafe, Sweden Johanna Zilliacus, Karolinska Institutet, Stockholm, Sweden Agneta Åkesson, Karolinska Institutet, Stockholm, Sweden Mattias Öberg, Karolinska Institutet, Stockholm, Sweden
Course organiser: Annika Hanberg, Institute of Environmental Medicine, Karolinska Institutet, Sweden.
Course committee: Annika Hanberg, Mattias Öberg and Marika Berglund, Karolinska Institutet, Sweden, Patrik Andersson and Karin Wiberg, Umeå University, Sweden, Kirsi Vähäkangas, University of Kuopio, Finland and Chris Talsness, Charité Universitätsmedizin Berlin, Germany.
The course was organised by RA-COURSES in collaboration with CASCADE Network of Excellence and the Finnish Graduate School in Toxicology.
Course participants and teachers at the course in Regulatory toxicology.
The objective of the course was to provide up-to-date information of the international, European and national regulatory processes concerning chemical risk assessment in humans.
The course included the following topics: Introduction to risk assessment, international, European and national regulatory organisations for chemicals and medicinal drugs, different categories of regulated chemicals, EU chemicals legislation-REACH, regulatory processes for food safety, occupational safety and environmental pollution, as well as alternative non-animal tests in regulatory processes. Also, development of new in vitro methods and new emerging fields (nanotoxicology) were discussed from the regulatory perspective.
The course consisted of lectures, panel discussion, computer exercises, group work and seminars by students.
The intended learning outcome was understanding of the regulatory processes and organisations in chemical risk assessment, knowledge of test-guidelines, GLP requirements and methodology development as well as direct personal contacts with senior scientists within regulatory toxicology and risk assessment.
Teachers: Stefano Bonassi, Pisa University, Italy Heidi Foth, Martin-Luther-Universität Halle, Germany Ursula Gundert Remy, Charité Berlin, Germany Helen Håkansson, Karolinska Institutet, Sweden Peter Kasper, Federal Institute for Drugs and Medical Devices, Germany Pekka Kurki, National Agency for Medicines, Finland Kimmo Louekari, ECHA Markku Pasanen, University of Kuopio, Finland Olavi Pelkonen, University of Oulu, Finland Raimo Pohjanvirta, National Public Health Institute, Finland Hannu Raunio, University of Kuopio, Finland Kai Savolainen, Finnish Institute of Occupational Health, Finland Beatriz SilvaLima, University of Lisbon, Portugal Hanna Tähti, Univerity of Tampere, Finland Harri Vainio, Finnish Institute of Occupational Health, Finland Kirsi Vähäkangas, University of Kuopio, Finland
Course organiser: Kirsi Vähäkangas, University of Kuopio, Finland.
Course committee: Kirsi Vähäkangas, Markku Pasanen, Jarkko Loikkanen, University of Kuopio, Finland, Helen Håkansson, Annika Hanberg, Mattias Öberg, Christina Rudén, Royal Institute of Technology, Sweden, Patrik Andersson, Umeå University, Sweden, Ibrahim Chahoud, Charité Universitätsmedizin Berlin, Germany.
The course was organised by RA-COURSES in collaboration with CASCADE Network of Excellence.
Course participants and teachers at the course in Reproductive and developmental toxicology.
The objective of the course was to 1) Provide an overview of basic aspects of embryology, female and male reproductive systems and regulatory toxicology, 2) Discuss experimental evaluation of the reproductive systems and interpretation of possible results and present some of the OECD guidelines, 3) Give an overview of virtual and in vitro methods and teratological studies to evaluate developmental toxicity and 4) Provide the participants with practical demonstrations regarding some of the methods employed.
The course included the following topics: Introduction to risk assessment, Basics of reproductive toxicology, Embryology, Molecular embryology, Computational embryology, Male and female reproductive systems, Spermatogenesis and oogenesis, Practical aspects of mating of laboratory animals, Maternal and fetal metabolism and kinetics of xenobiotics, Maternal toxicity, Evaluation of female and male fertility, Endocrine active compounds, Assays for screening of endocrine disruptors: uterotrophic and Hershberger assays, Assays for the evaluation of juvenile reproductive systems and for neurotoxicity, In vitro methods for evaluate developmental toxicology, Statistical analysis of developmental toxic effects, Legal requirements for evaluation of reproductive toxic effects of pesticides and medical products.
The course consisted of lectures, discussions, group work, video presentations, practical demonstrations and a round table discussion.
The intended learning outcome was to understand and interpret experimental data in terms of their biological significance for risk assessment.
Teachers: Rolf Bass, Charité Univerzitätsmedizin Berlin, Germany Ibrahim Chahoud, Charité Univerzitätsmedizin Berlin, Germany Burkhard Flink, Charité Univerzitätsmedizin Berlin, Germany Konstanze Grote, Charité Univerzitätsmedizin Berlin, Germany Tom Knudsen, U.S. Environmental Protection Agency, USA Reinhard Meister, Technische Fachhochschule Berlin, Germany Guiseppa Pennetta, University of Edinburgh, UK Rudolph Pfeil, Bundesinstitut für Risikobewertung, Germany Mehdi Shakibaei, Charité Univerzitätsmedizin Berlin, Germany Ellen Silbergeld, Johns Hopkins University, USA Ralf Stahlmann, Charité Univerzitätsmedizin Berlin, Germany Roland Solecki, Bundesinstitut für Risikobewertung, Germany Chris Talsness, Charité Univerzitätsmedizin Berlin, Germany Johanna Zilliacus, Karolinska Institutet, Sweden
Course organisers: Ibrahim Chahoud, Konstanze Grote and Chris Talsness, Charité Universitätsmedizin Berlin, Germany.
Course committee: Ibrahim Chahoud, Konstanze Grote and Chris Talsness, Charité Universitätsmedizin Berlin, Germany, Helen Håkansson, Annika Hanberg and Agneta Rannug, Karolinska Institutet, Sweden, Kirsi Vähäkangas and Markku Pasanen, University of Kuopio, Finland
The course was organised by RA-COURSES in collaboration with the Postgraduate programme in Environmental Factors and Health at Karolinska Institutet and CASCADE Network of Excellence.
Course participants and teachers at the course in Child health and the environment.
The objective of the course was to provide state-of-the-art knowledge about the environmental threats to child health in Europe in the context of health risk assessment. Overarching themes were be the specific susceptibility and exposure of the developing foetus, infant and child to environmental toxicants and the importance of modifying factors, e.g. nutrition and genetics.
The course included specific environmental areas of high concern for child health in Europe with focus on risk assessment of environmental factors. The following aspects were covered: Basic child health, nutrition and breast feeding, child development and maturation, exposure during childhood, asthma and allergy, organic and metal pollutants, endocrine disrupting chemicals, air quality, noise, electromagnetic fields and environmental burden of disease.
The course consisted of lectures, discussions, presentations of participants’ research projects and group work.
The intended learning outcome was the student should acquire knowledge and understanding of the specific susceptibility and exposure of the developing foetus, infant and child to environmental factors and the importance of modifying factors. The student should also acquire a professional attitude in interpretation of toxicological and epidemiological studies related to child health for use in health risk assessment. The course programme is available here.
Teachers: Anders Ahlbom, Institute of Environmental Medicine, Karolinska Institutet, Sweden Tobias Alfvén, Sachsska childrens hospital, Sweden Tom Bellander, Institute of Environmental Medicine, Karolinska Institutet, Sweden Marika Berglund, Institute of Environmental medicine, Karolinska Institutet, Sweden Anders Ekbom, Department of Medicine, Karolinska Institutet, Sweden Anita Gidlöf Gunnarsson, Occupational and Environmental Medicine, The Sahlgrenska Academy, Göteborg University, Sweden Olle Söder, Department of Woman and Child Health, Karolinska Institutet, Sweden Chris Talsness, Department of Toxicology, Charite Universitatsmedizin, Berlin, Germany Marie Vahter, Institute of Environmental Medicine, Karolinska Institutet, Sweden Magnus Wickman, Institute of Environmental Medicine, Karolinska Institutet, Sweden Agneta Yngve, Department of biosciences and nutrition, Karolinska Institutet, Sweden Johanna Zilliacus, Department of biosciences and nutrition, Karolinska Institutet, Sweden Mattias Öberg, Institute of Environmental Medicine, Karolinska Institutet, Sweden, Sweden
Course organiser: Mattias Öberg, Institute of Environmental Medicine, Karolinska Institutet, Sweden. Course committee: Annika Hanberg, Helen Håkansson, Agneta Rannug and Mattias Öberg, Karolinska Institutet, Sweden; Karin Wiberg, Umeå University, Sweden; Markku Pasanen, Jarkko Loikkanen, University of Kuopio, Finland and Ibrahim Chahoud, Charité Universitätsmedizin Berlin, Germany.
Contact person: Johanna Zilliacus, Karolinska Institutet, E-mail: johanna.zilliacus@ki.se
The course was organised by RA-COURSES, a project funded by European Union Marie Curie Actions and the Postgraduate programme in Environmental Factors and Health at Karolinska Institutet in collaboration with CASCADE Network of Excellence and the Division of Philosophy at the Royal Institute of Technology, Sweden.
Course participants and teachers at the course in Philosophy of Risk in Health Risk Assessment.
The objective of the course was to provide an overview of important aspects of interactions between science and policy in health risk assessment with a focus on strategies to handle scientific uncertainty.
The course included basic and applied concepts in theory of science (how can toxicological knowledge be generated?), decision theory (decision-making under uncertainty), ethics (theories about the distribution of risks and benefits), risk-benefit analysis (what is the value of a human life?), as well as principles and methods for risk communication (how are different risks perceived?).
The course consisted of lectures, discussions, exercises and group work. The result of the group assignment was presented orally and discussed.
The intended learning outcome was a better understanding of interactions between science and policy in the risk assessment process, knowledge in how science is used for decision-making, and increased experience in strategies to handle scientific uncertainty in health risk assessment as well as skills in risk communication.
Sara Belfrage, Royal Institute of Technology, Sweden
Tom Bellander, Karolinska Institutet, Sweden
Anna Beronius, Karolinska Institutet, Sweden
Leif Busk, Swedish Food Safety Authority, Sweden
Maria Feychting, Karolinska Institutet, Sweden
Lynn Frewer, Wageningen University, Netherlands
Annika Hanberg, Karolinska Institutet, Sweden
Sven Ove Hansson, Royal Institute of Technology, Sweden
Christina Rudén, Royal Institute of Technology, Sweden
Per Sandin, Swedish University of Agricultural Sciences, Sweden
Misse Wester, Royal Institute of Technology, Sweden
Lars Wiklund, RegSafe, Sweden
Johanna Zilliacus, Karolinska Institutet, Sweden
Course organiser: Christina Rudén, Royal Institute of Technology, Sweden.
Course committee: Christina Rudén, Royal Institute of Technology, Sweden, Annika Hanberg, Mattias Öberg, Karolinska Institutet, Sweden, Kirsi Vähäkangas, University of Kuopio, Finland
7. Exposure Assessment I: Chemical exposure assessment analysis and modelling
November 16-20, 2009
Umeå, Sweden
The course was organised by RA-COURSES, a project funded by European Union Marie Curie Actions in collaboration with CASCADE Network of Excellence.
Course participants and teachers at the course in Exposure Assessment I: Chemical exposure assessment analysis and modelling.
The objective of the course was to give an introduction into the field of exposure assessment with specific focus on chemical analysis and various modelling techniques.
The course included the following topics: Environmental pollutants, analytical chemistry, and strategies for sampling, modelling and interpretation of data. Quality issues were covered related to environmental concentrations data and exposure assessment processes as an integrated part of risk assessment protocols.
The course consisted of lectures, demonstrations of chemical analyses and group work.
The intended learning outcome was to reach an understanding of exposure assessment procedures and fundamental environmental analytical chemistry to be able to examine quality of analytical data and understand modelling techniques as a complementary tool to the use of data of environmental and human levels.
8. Health risk assessment II: Challenges in risk assessment
June 7-11, 2010
Stockholm, Sweden
The course was organised by RA-COURSES, a project funded by European Union Marie Curie Actions and the Postgraduate programme in Environmental Factors and Health at Karolinska Institutet.
Course participants and teachers at the course in Health Risk Assessment II: Challenges in Risk Assessment.
The objective
of the course was to provide knowledge and understanding on challenging issues in health risk assessment, i.e. health risk assessment of combined exposures and of the sensitivity of early exposure during development.
The course included
knowledge and understanding on challenging issues in health risk assessment, i.e. health risk assessment of combined exposures and of the sensitivity of early exposure during development. The course included state-of the art international procedures and guidance regarding health risk assessment of combined exposures and of the sensitivity of early exposure during development. A special focus was on developmental exposure and effects that occur at or persist until adulthood. International regulatory strategies to assess the health risks related to these effects were presented and the usefulness and limitations of these procedures discussed.
The course consists of lectures, discussions and group assignments.
The intended learning outcome was to acquired knowledge and understanding of the complexity of health risk assessment of combined exposures and of the sensitivity of early exposure during development. The student shall have acquired a professional attitude in assessing the strengths and weaknesses of complex risk assessments.
Course organiser: Annika Hanberg and Ulla Stenius, Institute of Environmental Medicine, Karolinska Institutet, Sweden
Course committee: Helen Håkansson, Johanna Zilliacus and Annika Hanberg, Karolinska Institutet, Sweden, Kirsi Vähäkangas and Jarkko Loikkanen, University of Kuopio, Finland, Ibrahim Chahoud, Charité Universitätsmedizin Berlin, Polly Boon, RIVM, Netherlands
9. Dietary Exposure Assessment: Concentration and consumption databases and probabilistic modelling
RIVM, Bilthoven, The Netherlands
October 25-29, 2010
The course was organised by RA-COURSES, a project funded by European Union Marie Curie Actions.
Course participants and teachers at the course in Dietary Exposure Assessment.
The objective of the course was to familiarize participants with dietary exposure assessment to toxic compounds and in particular with probabilistic modelling of dietary exposure.
The course included different items connected with dietary exposure assessment. These include among others:
Importance of exposure modelling in risk assessment
Models to integrate chemical levels and food consumption data to assess dietary exposure assessments (e.g. point estimate /deterministic approach / probabilistic approach, characteristics different approaches, acute vs. chronic exposure, which method most appropriate for which situation, data availability, recipe databases, databases to convert food as eaten into raw agricultural products)
Probabilistic modelling in particular:
Using the software programme @RISK with which participants will be taught the basic principles of probabilistic modelling using simple examples.
Performance of more complex examples of probabilistic modelling using the MCRA (Monte Carlo Risk Assessment) programme, including sensitivity and uncertainty analyses
Refinement of exposure modelling: processing effects, variability (when addressing the acute exposure to pesticides), levels assigned to samples with levels below the limit of detection
Pan-European modelling of exposure
Further developments in modelling of exposure: integration with effect modelling, risk – benefit modelling, exposure to more than one compound (risk-benefit, cumulative exposure).
Intake modeling in the field of nutrition
The course consisted of lectures and computer exercises.
The intended learning outcome was knowledge of exposure modelling and probabilistic modelling in particular, and how this is organised at the international level related to the evaluation/assessment of toxic compounds.
Jeanne de Vries, WUR, Department of Human Nutrition, The Netherlands
Hilko van der Voet, WUR-Biometris, The Netherlands
Jacob van Klaveren, RIVM, The Netherlands
Marcel van Raaij, RIVM, The Netherlands
Caroline van Rossum, RIVM, The Netherlands
Dagmar Wapperom, RIVM, The Netherlands
Johanna Zilliacus, Karolinska Institutet, Sweden
Course organiser: Polly Boon, RIVM, The Netherlands.
Course committee: Polly Boon and Jacob van Klaveren, RIVM, The Netherlands, Mattias Öberg and Marika Berglund, Karolinska Institutet, Sweden, Patrik Andersson and Karin Wiberg, Umeå University, Sweden
10. Statistics for toxicologists with focus on dose response modelling
March 21-25, 2011
Stockholm, Sweden
Participants and teachers at the course in Statistics for toxicologists with focus on dose response modelling.
The objective of the course was to provide knowledge on dose response modelling in toxicology, including benchmark dose analysis, for risk assessment of chemicals.
The course included the following topics:
Dose-response modelling of continuous, ordinal and quantal data, The benchmark dose method and traditional NOAEL approach in risk assessment, Dose response modelling with covariates, Calculation of relative potencies, Calculation of sensitivity differences between populations and Dose-response with litter effects.
The course consisted of lectures and computer exercises.
The intended learning outcome was to get experience of the use of dose response modelling in toxicology and to understand the possibilities and the difference of such procedures compared to the traditional NOAEL approach.